DISTRIBUTION OF LITHIUM INTO CEREBROSPINAL-FLUID, BRAIN-TISSUE AND BILE IN MAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (7) , 333-335
Abstract
The concentration of Li was determined in plasma, CSF and bile in 2 groups of 5 and 6 patients after oral administration of lithium carbonate in each group. In a 3rd group of 7 patients the Li concentration in the brain and also in the CSF and the plasma was determined in the steady state. The influx into CSF was delayed in contrast to that into plasma and bile. The elimination was biexponential. The mean plasma half-life of lithium carbonate was 21 h. The concentration ratio between CSF and bile, respectively, and plasma was 0.44 .+-. 0.03 and 1.48 .+-. 0.36 in steady state. Two percent of the given dose was eliminated with the bile within 24 h. There was no concentration difference in steady state between that for CSF and both white and grey brain matter. The concentration of Li in CSF may represent the brain concentration. Li is a useful and reliable agent in the therapy of manic depressive disorders.

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