Graft-vs-host reaction

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Abstract
Observations surrounding the clinical manifestations and pathological studies of a neonate who died at 9 wk of age, indicate that distinctive cutaneous, histopathologic and ultrastructural findings occur when graft vs. host reaction (GVHR) complicates combined immune deficiency syndrome (CIDS). The prominence and specificity of the epidermal lesions, particularly a necrotic cell that occurs in association with satellite lymphocytes (satellite cell necrosis (SCN)), indicate that a cutaneous biopsy should be performed to facilitate an early definitive diagnosis. Dermatologists can recognize GVHR at the bedside and establish the diagnosis with the pathological findings obtained from the skin biopsy.

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