Ineffectiveness of 688A (N-Phenoxyisopropyl-N-Benzyl- -Chloroethylamine Hydrochloride) in Treatment of Essential Hypertension

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Abstract
Summary Oral administration of 688A, an agent which causes adrenergic and sympathetic blockade, did not ameliorate the condition of 8 patients with essential hypertension when administered over a period of from 2 to 26 weeks. A statistically significant, but clinically unimpressive decrease of supine systolic and diastolic pressures occurred in only 1 of these patients; in another, supine arterial pressures were maintained in the presence of “blockade” and tolerance to a daily dosage of 1200 mg was established at the end of 4 weeks.