Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes
- 1 January 1994
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 38 (1) , 126-129
- https://doi.org/10.1128/aac.38.1.126
Abstract
The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.Keywords
This publication has 23 references indexed in Scilit:
- Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.1993
- RS-61443—A PHASE I CLINICAL TRIAL AND PILOT RESCUE STUDY 1Transplantation, 1992
- In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443.1991
- Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents.1991
- Lymphocyte‐Selective Cytostatic and Immunosuppressive Effects of Mycophenolic Acid in Vitro: Role of Deoxyguanosine Nucleotide DepletionScandinavian Journal of Immunology, 1991
- “Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein AAnalytical Biochemistry, 1981
- Infection of human B lymphocytes with high multiplicities of Epstein-Barr virus: Kinetics of EBNA expression, cellular DNA synthesis, and mitosisVirology, 1981
- Analysis of the Transformation of Human Lymphocytes by Epstein-Barr VirusIntervirology, 1979
- The Role of de novo Purine Synthesis in Lymphocyte TransformationPublished by Wiley ,1977
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970