A hybrid gene to express protein epitopes from both sporozoite and merozoite surface antigens of Plasmodium falciparum
- 1 October 1988
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 97 (3) , 373-382
- https://doi.org/10.1017/s0031182000058790
Abstract
The DNA coding for parts of the repetitive amino acid sequence of the Plasmodium falciparum circumsporozoite protein has been spliced to a sequence encoding part of the precursor to the major merozoite surface antigens, to produce a hybrid gene. Expression in Escherichia coli produces a protein with antigenic determinants from both malaria proteins. Antibodies raised against the expressed material react with both a peptide derived from the circumsporozoite repeat sequence, and the merozoite surface molecule. Hybrid molecules of this type may be the basis of a malaria vaccine.This publication has 17 references indexed in Scilit:
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