Endothelial injury of arteries following catheterisation with polyethylene tubes: experimental studies on rabbit aorta using the Seldinger technique

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Abstract
The effect of catheterization on the rabbit aortic wall is investigated employing a technique identical to that used for continuous monitoring of blood pressure in humans. The catheters were introduced into the aorta through the right femoral artery of the rabbit using the Seldinger technique, except that the catheters were introduced directly into the femoral artery and not percutaneously. Catheterization for 24 h was followed by intimal and medial injuries. A 3-60% (mean 20.4%) de-endothelialization of the aortic surfaces was observed. Some complications observed after continuous registration of blood pressure in humans are explained. Case histories are referred to in which the brachial artery was catheterized.