THYROTROPHIN-RELEASING HORMONE INHIBITS THE PENTAGASTRIN STIMULATED GASTRIC SECRETION IN MAN. A DOSE RESPONSE STUDY
- 1 March 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 10 (3) , 281-286
- https://doi.org/10.1111/j.1365-2265.1979.tb02082.x
Abstract
Actions of thyrotrophin-releasing hormone (TRH) have generally been confined to the CNS. The effect of increasing doses of TRH i.v. (8, 40, 200 and 1000 .mu.g/h) on pentagastrin-stimulated gastric secretion was studied in 10 normal individuals. All doses caused stepwise inhibition of gastric juice (volume), acid and pepsin output. When employing the lartest dose of i.v. TRH (1000 .mu.g/h) the inhibition was 44% for gastric volume, 51% for acid output and 57% for pepsin output. TRH inhibits gastric secretion and TRH has actions outside the CNS in man.This publication has 9 references indexed in Scilit:
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