The mechanism of internuclear transmission of SV40-induced complement fixation antigen in heterokaryocytes.
- 1 March 1968
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 59 (3) , 769-776
- https://doi.org/10.1073/pnas.59.3.769
Abstract
Fusion of transformed human, monkey and hamster cells with cells of various origins results in the transmission of ICFA [induced complement fixation antigen] to the recipient nuclei. This transmission is insensitive to FUdR [5-fluoro-2[image]-deoxyuridine], indicating that DNA synthesis is not necessary. Actinomycin D inhibits ICFA transmission, indicating the necessity of new mRNA synthesis for transmission. Cycloheximide also inhibits the transmission of ICFA, indicating that protein synthesis is necessary for transmission; simple diffusion does not account for the observed internuclear protein migration.This publication has 7 references indexed in Scilit:
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