VITAMIN D COMPLEX IN KERATOCONUS

11 June 1938

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 110 (24) , 1993-1994
https://doi.org/10.1001/jama.1938.02790240017006

Abstract

Graves¹describes keratoconus as "a hyperbolic bulging of the central part, or whole, of the cornea, with thinning of the center, unaccompanied by inflammation or increased tension." In a recent paper from the department of pharmacology of Columbia University College of Physicians and Surgeons, Blackberg and I²reported the consistent production of keratoconus in dogs fed a vitamin D deficient, low calcium diet. We have repeated these experiments on rats this past winter and have noted similar results. In our experiments on dogs, we enucleated the eyes of some of them. These eyes were examined microscopically. The results of our pathologic examinations, corroborated by Drs. Reese and Laidlaw, have been published.³The basic changes in the corneas were thinning of the epithelium, edema of the substantia propria with irregularity of its lamellar structure and reduplication of the endothelium, with hydropic degeneration. Nineteen eyes (twelve patients) with keratoconus

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