Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide
- 22 October 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 59 (8) , 1257-1258
- https://doi.org/10.1212/wnl.59.8.1257
Abstract
Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Aβ) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first evidence that statins in clinically relevant dosages indeed affect cerebral cholesterol metabolism. However, these changes were not associated with altered intrathecal secretion of Alzheimer Aβ.Keywords
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