ENHANCED INTERLEUKIN-1 AND DEPRESSED INTERLEUKIN-2 PRODUCTION IN JUVENILE ARTHRITIS

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  • 1 June 1986
    • journal article
    • research article
    • Vol. 13  (3) , 598-603
Abstract
Blood mononuclear cells from a total of 23 children with juvenile arthritis were stimulated in vitro to produce interleukin 1 (IL-1) and interleukin 2 (IL-2) and compared with age matched healthy controls. Peripheral blood monocytes from patients with juvenile arthritis produced a higher amount of IL-1 than controls, whereas peripheral blood lymphocytes from the same patients produced lower amount of IL-2 than controls. These findings could not be explained by concurrent therapy. The increase of IL-1 production was more marked in patients with active disease and therefore may have been secondary to the pathological process. However, the decrease of IL-2 production did not depend on disease activity, thus suggesting an immunoregulatory abnormality.