Increased populations of endocrine cells in Crohn's ileitis
- 1 January 1987
- journal article
- Published by Springer Nature in Virchows Archiv
- Vol. 410 (5) , 391-396
- https://doi.org/10.1007/bf00712758
Abstract
Hyperplasia of nerves has been described previously in Crohn's disease. To determine whether similar alteration of the enteric endocrine system occurs, endocrine cells of the ileal epithelium were quantified in typical cases of the disease. In the ileum from patients with Crohn's disease, there was an increase in the endocrine cell population, as visualised by immunostaining of chromogranin. Quantification of endocrine cell numbers showed significant increases in both macroscopically uninvolved (i.e. histologically normal) (35.0±3.8, cells per unit length of muscularis mucosae mean ±SEM,PPP<0.05).Keywords
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