Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses
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- 1 July 2009
- journal article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 86 (5) , 507-510
- https://doi.org/10.1038/clpt.2009.103
Abstract
Drug repositioning refers to the discovery of alternative uses for drugs—uses that are different from that for which the drugs were originally intended. One challenge in this effort lies in choosing ...Keywords
This publication has 13 references indexed in Scilit:
- Statin-Induced Inhibition of 3-Hydroxy-3-Methyl Glutaryl Coenzyme A Reductase Sensitizes Human Osteosarcoma Cells to Anticancer DrugsThe Journal of Pharmacology and Experimental Therapeutics, 2008
- Drug—target networkNature Biotechnology, 2007
- Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesisBlood, 2007
- Rare Diseases, Orphan Drugs, and Orphaned PatientsMolecular Interventions, 2006
- Drug repositioning: identifying and developing new uses for existing drugsNature Reviews Drug Discovery, 2004
- The Unified Medical Language System (UMLS): integrating biomedical terminologyNucleic Acids Research, 2004
- Letter to the EditorLupus, 2003
- The price of innovation: new estimates of drug development costsJournal of Health Economics, 2003
- Antitumor Activity of Thalidomide in Refractory Multiple MyelomaNew England Journal of Medicine, 1999
- Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic TrioxideNew England Journal of Medicine, 1998