Intracranial self-stimulation in mice using a modified hole-board task: Effects of d-amphetamine
- 1 May 1980
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 68 (2) , 169-171
- https://doi.org/10.1007/bf00432136
Abstract
Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated reliable selfstimulation rates when given the opportunity to break a photobeam in a modified hole-board task. Selfstimulation rates were enhanced by low dosages of d-amphetamine but were depressed by high dosages. The dose-dependent effects of amphetamine could not be accounted for by changes in exploratory hole-board activity and were discussed in terms of an interaction between the rewarding properties of electrical brain stimulation and the reinforcing properties of amphetamine administration.This publication has 5 references indexed in Scilit:
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