The effect of lipid peroxidation on transport function in human erythrocytes.

  • 1 January 1983
    • journal article
    • Vol. 42, S58-62
Abstract
We have reported that the generation of oxygen free radicals within human red cells resulting from treatment with phenazine methosulfate (PMS) induces several toxic effects in membranes; lipid peroxidation, a binding of methemoglobin and a loss of intracellular K+. The specific K+ carriers are only slightly inhibited (Na+, K+ pump; Na+, K+ cotransport) and the K+ loss is mainly due to an increase in the passive K+ permeability. This could result from a toxic effect on the membrane such as lipid peroxidation or methemoglobin binding. The use of "oxygen free radical scavenger" molecules and pro-oxidative molecules showed that the PMS-dependent increase in passive K+ permeability is consequent to lipid peroxidation rather than to methemoglobin binding.

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