Sorting of Mannose 6-Phosphate Receptors Mediated by the GGAs
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- 1 June 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5522) , 1712-1716
- https://doi.org/10.1126/science.1060750
Abstract
The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors contain acidic-cluster-dileucine signals that direct sorting from the trans-Golgi network to the endosomal-lysosomal system. We found that these signals bind to the VHS domain of the Golgi-localized, γ-ear–containing, ARF-binding proteins (GGAs). The receptors and the GGAs left the trans-Golgi network on the same tubulo-vesicular carriers. A dominant-negative GGA mutant blocked exit of the receptors from the trans-Golgi network. Thus, the GGAs appear to mediate sorting of the mannose 6-phosphate receptors at the trans-Golgi network.Keywords
This publication has 16 references indexed in Scilit:
- Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate ReceptorScience, 2001
- Signal-binding Specificity of the μ4 Subunit of the Adaptor Protein Complex AP-4Journal of Biological Chemistry, 2001
- μ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptorsThe EMBO Journal, 2000
- GeophysicistsEos, 2000
- A Family of ADP-Ribosylation Factor Effectors That Can Alter Membrane Transport through thetrans-GolgiMolecular Biology of the Cell, 2000
- Vear, a Novel Golgi-associated Protein with VHS and γ-Adaptin “Ear” DomainsJournal of Biological Chemistry, 2000
- Systematic Mutational Analysis of the Cation-independent Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Cytoplasmic DomainJournal of Biological Chemistry, 1997
- A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with MembranesJournal of Biological Chemistry, 1996
- The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.The Journal of cell biology, 1992
- STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORSAnnual Review of Biochemistry, 1992