Effects of Catecholamines on Urinary Calcium and Phosphorus in Intact and Parathyroidectomized Rats1

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Abstract
The effects of the catecholamines, epinephrine, norepinephrine and isoproterenol, on the renal excretion of calcium and inorganic phosphate have been studied in intact and 1-day-parathyroidectomized, fed rats. Urine was collected for the 2-hr period immediately following an oral water load and the subcutaneous administration of from 0.006 to 0.5 mg/kg of the catecholamines. In general, the responses to epinephrine and to norepinephrine were similar; isoproterenol gave responses which differed from those seen with the natural hormones. Whereas epinephrine and norepinephrine induced a hypercalciuric response both in intact and in parathyroidectomized rats, isoproterenol produced a hypocalciuric response in parathyroidectomized rats and caused no effect on urinary calcium excretion in intact rats. The phosphaturic response to epinephrine was variable, depending upon the dose and upon the presence or absence of the parathyroids; norepinephrine was consistent in producing hyperphosphaturia. Hypophosphaturia was the most frequent response to isoproterenol. The effects of the catecholamines on urinary volume and creatinine were also studied. Isoproterenol was markedly antidiuretic in its action; the natural hormones were diuretic. Creatinine excretion was little affected by any of the catecholamines. The relation of these findings to an earlier study involving the effects of the catecholamines on serum calcium and phosphorus levels is discussed. A female patient with a pheochromocytoma was found to have an abnormally high level of urinary calcium excretion, which returned to normal levels following the removal of the tumor. (Endocrinology75: 78, 1964)

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