Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases
- 1 November 1985
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 18 (5) , 567-573
- https://doi.org/10.1002/ana.410180510
Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.This publication has 23 references indexed in Scilit:
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