Nasal Pharmacodynamics of Brompheniramine in Perennial Rhinitis
- 1 January 1988
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 114 (1) , 63-67
- https://doi.org/10.1001/archotol.1988.01860130067017
Abstract
• This study evaluated the relationship between brompheniramine maleate and changes in nasal reactivity. Ten subjects with moderate-to-severe perennial rhinitis took brompheniramine for seven days using either a standard formulation or sustained-release preparation. Nasal aerodynamics and response to histamine were assessed at the end of the week. Despite varying doses of brompheniramine maleate (12 to 32 mg/d), there was no significant difference in nasal reactivity to histamine or in changes of nasal airflow, indicating that low doses of brompheniramine are highly effective in blocking histamine1 receptors in the nasal mucosa. (Arch Otolaryngol Head Neck Surg 1988;114:63-67)This publication has 12 references indexed in Scilit:
- The applicability of rhinomanometry in nonatopic children: Comparison of three techniquesJournal of Allergy and Clinical Immunology, 1985
- The pharmacokinetics and antihistaminic effects of brompheniramineJournal of Allergy and Clinical Immunology, 1982
- Local intranasal immunotherapy for ragweed allergic rhinitis I. Clinical responseJournal of Allergy and Clinical Immunology, 1981
- Pharmacologic prophylaxis of allergic rhinitis: Relative efficacy of hydroxyzine and chlorpheniramineJournal of Allergy and Clinical Immunology, 1981
- The effect of H and H blockade on cutaneous histamine response in manJournal of Allergy and Clinical Immunology, 1980
- Performance studies with antihistamines.British Journal of Clinical Pharmacology, 1978
- Basic study of nasal provocative testEuropean Archives of Oto-Rhino-Laryngology, 1978
- The human nasal cyclePlastic and Reconstructive Surgery, 1977
- Basic study of nasal provocative test first report: Side, site of the nose, size of site and allergen amountEuropean Archives of Oto-Rhino-Laryngology, 1977
- An instrument for measuring the effective cross-sectional nasal airwayJournal of Allergy, 1966