Deficiency of Fat-Soluble Vitamins in Treated Patients with Pancreatic Insufficiency

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Abstract
Deficiency of fat-soluble vitamins (A, D, E and K) was evaluated in 15 patients with exocrine pancreatic insufficiency secondary to chronic alcoholic pancreatitis. Mild to moderate steatorrhea was present in all patients despite oral pancreatic enzyme therapy for 27 .+-. 4 mo. (mean .+-. SE). Deficiency of a single fat-soluble vitamin was seen in 6 patients and deficiency of 2 fat-soluble vitamins was seen in 2 patients. One patient was deficient in 3 fat-soluble vitamins. Deficiency of vitamins A and E was most frequent. Treatment with specific vitamin supplements resulted in correction of these vitamin deficiencies. Evidently deficiency of a single or multiple fat-soluble vitamins is frequent even in treated patients with pancreatic insufficiency.

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