Leukemogenic Filterable Agent from Estrogen-Induced Thymic Lymphoma in RF Mice.

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Abstract
Summary The role of a latent virus in induction of lymphoma by diethylstilbestrol in Rf mice was investigated. Thymic lymphoma developed in 62.9% and non-thymic lymphoma in 8.6% of DES-treated mice within 400 days of age. Unlike radiations, estrogen failed to induce myeloid leukemia in Rf mice. Cell-free filtrates of one thymic lymphoma (No. 82) was lymphomogenic; that of 2 other lymphomas was apparently inactive. Whereas filtrate 82 caused lymphomas in 41.7% of 48 mice within 9 months of age, the incidence of lymphoma in 78 mice injected with the other 2 filtrates was 2.6%; this is about the spontaneous lymphoma incidence in Rf mice within 9 months of age. The development of 17 diverse tumors other than lymphomas in mice injected with filtrate 82 pointed to the presence of a polyoma virus in this filtrate contaminating the leukemia virus.