Ocular Toxicity of Experimental Intravitreal DMSO
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology- Cutaneous and Ocular Toxicology
- Vol. 2 (2-3) , 193-200
- https://doi.org/10.3109/15569528309065312
Abstract
Dimethyl sulfoxide (DMSO) is a universal solvent which may be a suitable solvent for intraocular drugs. In this experimental study, the toxic effect of intravitreal DMSO in rabbits is examined. Single and multiple intravitreal injections of 1%, 10%, 50%, and 100% DMSO were made. Single injections produced no long-term toxic effect. Toxic effects were seen in the lens with cataract formation when injected with multiple doses of DMSO. Transient retinal toxicity was seen 1 hr after injection of DMSO, but cleared completely in 1 month.Keywords
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