Spironolactone. III. Canrenone—maximum and minimum steady‐state plasma levels

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Abstract
Steady-state plasma levels of canrenone have been examined in 23 healthy men who received repeated doses of spironolactone for 15 days. The dose regimens were 200 mg once a day and 50 mg 4 times a day. With both treatments the steady-state levels were reached after 3 to 4 days. With once-a-day treatment, the maximum and minimum steady-state levels were about 500 and 100 nglml, respectively. The minimum levels with treatment 4 times a day were about 200 ng/ml. The post steady-state half-life of canrenone with once-a-day treatment (19.2 ± 6.57 hr) was longer (p < 0.01) than the half-life obtained in the 4-times-a-day treatment (12.5 ± 3.39 hr). The former half-life was similar to the log-linear phase half-life of canrenone in the single-dose studies.

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