OBSERVATIONS ON THE EFFECTS OF ALKYLATING AGENTS IN HUMAN NEOPLASTIC DISEASE

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Abstract
An attempt has been made to show that certain chemotherapeutic agents, known to produce significant degrees of remission in the malignant hemopoietic diseases (leukemia, malignant lymphoma, etc.), also may cause significant and at times prolonged degrees of regression of metastatic or recurrent lesions of the "solid" tumor type. While chemotherapeutic agents are most useful when administered on a systemic basis in the presence of widely disseminated cancer there are certain situations in which their use locally has proved to be beneficial (e. g., transitional cell carcinoma of the urinary bladder). It is becoming increasingly evident that, with every new chemical agent worthy of clinical trial, widespread testing against a wide spectrum of human malignant diseases is indicated, not only at different dosage levels but also by different modes of administration.

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