Fluoxetine

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Abstract
The ability of tricyclic antidepressant drugs to inhibit the prejunctional reuptake of norepinephrine and serotonin may be responsible for their antidepressant effect. The ability of these drugs to block muscarinergic, H1-histaminergic, and α1-adrenergic receptors may explain their side effects, such as dryness of the mouth, sedation, and hypotension. The development of drugs that inhibit the reuptake of norepinephrine and serotonin but do not have receptor-blocking effects started in the early 1970s.Fluoxetine (Prozac), a selective inhibitor of serotonin reuptake, is now the most widely prescribed antidepressant drug in the United States and is also commonly prescribed . . .