Increased Insulin Responsiveness in Isolated Rat Hepatocytes Incubated with Free Fatty Acid-Poor Albumin1
- 1 August 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 23 (08) , 362-364
- https://doi.org/10.1055/s-2007-1003701
Abstract
Freshly isolated rat hepatocytes incubated in a medium containing bovine serum albumin partially purified by charcoal treatment at pH 3 are three times more responsive to insulin with regard to α-aminoisobutyric acid uptake than those incubated in medium containing regular bovine serum albumin. This finding should facilitate future work in isolated hepatocytes, a cell system that for the most part has been considered relatively unresponsive to insulin.Keywords
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