Thermal Stability of DNA Interacting with Furazolidone and Cu(II) Ions
Open Access
- 1 April 1983
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 38 (3-4) , 290-293
- https://doi.org/10.1515/znc-1983-3-421
Abstract
Furazolidone, on complexing with DNA, led to its thermal stabilization. The increase in transition temperature of DNA (ΔTm) increased linearly with % A - T content. Increasing concentration of Cu(II) ions progressively lowered the transition tem perature of DNA, but Cu(II) ions were not equally effective in lowering the transition temperature of furazolidone-DNA complex. When equimolar amounts of Cu(II) ions and furazolidone were used, the stabilisation effects of furazolidone prevailed over the destabilisation effect of Cu(II) ionsKeywords
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