Glucose‐6‐Phosphate Dehydrogenase (G‐6‐PD) Hamburg, a New Variant with Chronic Nonspherocytic Haemolytic Anaemia

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Abstract
A new variant of G‐6‐PD with chronic non‐spherocytic haemolytic anaemia and very low activity, named G‐6‐PD Hamburg, was partially purified and biochemically characterized. It was found to have very high lability, an unusually high Km for G‐6‐P (2000 μM), increased utilization rates for 2‐desoxy G‐6‐P (133%) and galactose‐6‐phosphate (87%) and an abnormal pH‐activity curve. The electrophoretic mobility seemed to be normal. The leukocytes also revealed diminished G‐6‐PD activity. No impairment of bactericidal activity of neutrophilic granulocytes, as shown by a normal nitroblue tetrazolium reduction, could be demonstrated.