Cell number deficiencies in the nervous system of dwarf mice
- 1 November 1965
- journal article
- research article
- Published by Wiley in The Anatomical Record
- Vol. 153 (3) , 325-333
- https://doi.org/10.1002/ar.1091530313
Abstract
A quantitative histologic investigation has been performed on the nervous system and striated muscle of the dwarf mouse (Snell's Strain).The number of nerve cells in the spinal cord of the dwarf mouse is half of that seen in the normal mouse. These data are fully confirmed by separate counts of efferent and afferent fibers of the spinal roots. Spinal root fiber diameters are similar in both normal and dwarf mice. The number of muscle fibers in the peroneus longus muscle is about the same in both the normal and in the dwarf mouse; the diameter of each muscle fiber, however, is reduced in the dwarf.At the muscular level the deficiency manifests itself as a volumetric reduction in the muscle fibers; whereas, at the level of the spinal cord there is a reduced number of nerve cells. It follows from these observations that in the dwarf mouse the ratio of nerve fibers to muscle fibers within a motor unit is altered so that each motor neuron innervates more muscle fibers than in the normal mouse. This fact could explain the peculiar movements of the dwarf mouse.Keywords
This publication has 9 references indexed in Scilit:
- Histology of the anterior hypophysis, thyroid and gonads of two types of dwarf miceThe Anatomical Record, 1964
- THE ANATOMICAL AND PHYSIOLOGICAL EFFECTS OF PRENATALLY ADMINISTERED SOMATOTROPHIN ON CEREBRAL DEVELOPMENT IN RATSJournal of Endocrinology, 1961
- Heterogeneity of Ion Exchange ResinsScience, 1960
- The Dwarf Mouse--An Animal with Secondary Myxedema.Experimental Biology and Medicine, 1959
- An hereditary anterior‐pituitary deficiency in the mouseThe Anatomical Record, 1930
- Numbers and contraction-values of individual motor-units examined in some muscles of the limbProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1930
- DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSEProceedings of the National Academy of Sciences, 1929
- Remarks on some aspects of reflex inhibitionProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1925
- Comparative studies on the growth of the cerebral cortex. VI. Part I. On the increase in size and on the developmental changes of some nerve cells in the cerebral cortex of the albino rat during the growth of the brain. Part II. On the increase in size of some nerve cells in the cerebral cortex of the Norway rat (Mus norvegicus), compared with the corresponding changes in the albino ratJournal of Comparative Neurology, 1918