Carcinoma in Situ

Publisher Website
Google Scholar
Abstract
UNDER the term carcinoma in situ, Broders,1 in 1932, described a group of lesions characterized by the appearance of certain abnormal types of cells within the normal confines of the epithelial layer. These cells manifest in appearance or in behavior various features that are characteristic of the cells of malignant tumors. They may entirely replace the normal epithelial cells over considerable distances, but they do not pass the barrier of the basement membrane and invade underlying tissues. The majority of these lesions were considered for many years to be "precancerous." Today, the preponderance of opinion is that they are a . . .