KINETICS OF DRUG DECOMPOSITION .62. KINETICS OF PENICILLIN-G POTASSIUM-SALT (PGP) THERMAL-DEGRADATION IN SOLID-PHASE
- 1 January 1980
- journal article
- research article
- Vol. 32 (1) , 55-62
Abstract
The kinetics of degradation of penicillin G K salt (PGP) in solid phase in the temperature range 70-140.degree. C were investigated. The obtained sigmoidal curves were interpreted in terms of the Prout-Tompkins kinetics. The appropriate mathematical equations were derived for the induction and acceleration periods which enable to calculate the degradation half-time, t0.1 value and the induction time (t''). The Arrhenius plot shows the isokinetic point where the rates of reaction for both periods are identical.This publication has 2 references indexed in Scilit:
- KINETICS OF DRUG DECOMPOSITION .61. KINETICS OF VARIOUS AMPICILLIN FORMS DEGRADATION IN SOLID-PHASE1980
- Thermal Decomposition of Amorphous β-Lactam AntibacterialsJournal of Pharmaceutical Sciences, 1977