Intrinsic Factor Inhibitors, Pernicious Anemia, and Autoimmunity
- 8 September 1966
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 275 (10) , 562
- https://doi.org/10.1056/nejm196609082751014
Abstract
IN 1959, Li et al1 reported a case of pernicious anemia due to the presence of an in vivo intrinsic factor inhibitor, diagnosed in childhood, with a twenty-five-year follow-up. Since then, "defective absorption of vitamin B12 due to intrinsic factor inhibitor in gastric secretion" has been part of the etiologic classification of the megaloblastic anemias due to vitamin B12 deficiency. In the intervening years, it was demonstrated that blood group substances may block intrinsic factor action and it was speculated that secretors of blood group substance into their gastric juice may, to a variable extent, block the action of . . .Keywords
This publication has 5 references indexed in Scilit:
- INTRINSIC-FACTOR ANTIBODIES IN GASTRIC JUICE OF PERNICIOUS-ANÆMIA PATIENTSThe Lancet, 1966
- Coexistent Pernicious Anemia and Malabsorption in Four PatientsAnnals of Internal Medicine, 1966
- The effect of prednisolone on gastric mucosal histology, gastric secretion, and vitamin B 12 absorption in patients with pernicious anemia.Journal of Clinical Investigation, 1966
- Intrinsic FactorGastroenterology, 1965
- Intestinal malabsorption of vitamin B12 in pernicious anemiaMetabolism, 1964