Hydrocortisone effects on cell proliferation: Specificity of response among various cell types
- 1 March 1977
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 1 (2) , 147-155
- https://doi.org/10.1016/0309-1651(77)90035-2
Abstract
The effect of 14 micrometer hydrocortisone (HC) on the proliferative activity of various vertebrate cell lines has been measured. Such activity in human deploid cell line WI-38 was enhanced by HC addition whereas in a number of other vertebrate cell lines under identical conditions HC was inhibitory to growth. We examined the effects of HC on normal human diploid cells other than WI-38; some were stimulated, some inhibited and some were unresponsive. The results suggest that cells derived from different human tissues retain in vitro some aspects of their cell-specific hormonal responses.Keywords
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