bcl-2 Gene Rearrangements in Follicular Lymphomas

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Abstract
The t(14;l 8) chromosome translocation is the cytogenetic hallmark of follicular lymphomas. The study of this translocation at the molecular level has led to the discovery of a new oncogene, bcl-2. This gene is the first member of a new class of oncogenes: the regulators of programmed cell death. It is activated by the translocation- induced gene rearrangement, and the malignant cells become virtually immortal. Detection of bcl-2 gene rearrangements is important not only for diagnosis, but also for monitoring patients with follicular lymphomas throughout the course of their disease.

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