A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

1 May 1998

journal article
Published by Wolters Kluwer Health in Neurology

Vol. 50 (5) , 1458-1461
https://doi.org/10.1212/wnl.50.5.1458

Abstract

In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.

Keywords

GENETIC POLYMORPHISM
CIGARETTE
SMOKING
ALLELE
MONOAMINE
PARKINSON9S
PACK
MAO

This publication has 1 reference indexed in Scilit:

Concordance of positive and negative symptoms in coaffected sib-pairs with schizophrenia
American Journal of Medical Genetics, 1997