Cephalosporin antibiotics. Synthesis and antimicrobial activity of 7.BETA.-(2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido)cephalosporin derivatives.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (8) , 1020-1033
- https://doi.org/10.7164/antibiotics.36.1020
Abstract
Cephalosporins with a 7.beta.-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido] side chain were synthesized; their in vitro inhibitory potency was established. The compounds exhibited a strong antibacterial activity against various gram-positive and gram-negative bacteria. The antimicrobial activity was related to the oxime substituent and the C-3 substituent. Selected amino-1,2,4-thiadiazolyl-cephems showed a prolonged half-life in mice.This publication has 3 references indexed in Scilit:
- GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activityAntimicrobial Agents and Chemotherapy, 1980
- Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activitiesAntimicrobial Agents and Chemotherapy, 1979
- SK&F 75073, New Parenteral Broad-Spectrum Cephalosporin with High and Prolonged Serum LevelsAntimicrobial Agents and Chemotherapy, 1978