The Formation of anN-Hydroxymethyl Intermediate in theN-Demethylation ofN-Methylcarbazolein vivoandin vitro
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 6 (5) , 265-274
- https://doi.org/10.3109/00498257609151638
Abstract
1. The metabolism of N-methylcarbazole has been studied in several mammalian species, both in vivo and in vitro. 2. An important metabolite after incubation of N-methylcarbazole with liver microsomes in vitro was identified as N-hydroxymethylcarbazole. 3. This metabolite was also found as a conjugate (probably the O-glucuronide) in the urine of some species. 4. N-Hydroxymethylcarbazole decomposed spontaneously in solution at pH 7.4 to formaldehyde and carbazole; this breakdown was enhanced by incubation with liver microsomes from several species, especially the guinea-pig. 5. The role of N-methyl hydroxylation, compared with N-oxidation, in the mechanism of N-dealkylation of non-basic N-methyl compounds is discussed.This publication has 22 references indexed in Scilit:
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