Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm?
- 1 April 1994
- journal article
- review article
- Published by Wolters Kluwer Health in Stroke
- Vol. 25 (4) , 904-908
- https://doi.org/10.1161/01.str.25.4.904
Abstract
Background Endothelin-1 is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. Its long-lasting vasoconstrictor and hypertensive action has been well documented in several species, including humans. Summary of Review It is generally accepted that endothelin-1 may contribute to the pathogenesis of a number of cardiovascular diseases. In the cerebral vasculature, endothelin-1 has been proposed as a key mediator of cerebral vasospasm following subarachnoid hemorrhage. Availability of endothelin-1 antagonist provided a pharmacologic tool to test the role of endothelin in the development of vasospasm. Conclusions This brief review is focused on the controversial results reported by different groups concerning the possible role of endothelin-1 in narrowing of cerebral arteries exposed to autologous bloodKeywords
This publication has 58 references indexed in Scilit:
- An endothelin ETA receptor antagonist, FR139317, ameliorates cerebral vasospasm in dogsLife Sciences, 1993
- BQ-123, a peptidic endothelin ETA receptor antagonist, prevents the early cerebral vasospasm following subarachnoid hemorrhage after intracisternal but not intravenous injectionLife Sciences, 1993
- Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptorLife Sciences, 1992
- Phosphoramidon inhibits the conversion of intracisternally administered big endothelin-1 to endothelin-1Biochemical and Biophysical Research Communications, 1991
- Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzymeBiochemical and Biophysical Research Communications, 1990
- Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cellsBiochemical and Biophysical Research Communications, 1990
- Endothelin-3 concentrations in human plasma: The increased concentrations in patients undergoing haemodialysisBiochemical and Biophysical Research Communications, 1990
- Identification and characterization of endothelin converting activity in cultured bovine endothelial cellsBiochemical and Biophysical Research Communications, 1990
- Endothelin and the production of cerebral vasospasm in dogsBiochemical and Biophysical Research Communications, 1989
- Reversal of experimental delayed cerebral vasospasm by angiotensin-converting enzyme inhibitionJournal of Neurosurgery, 1981