Oxygen Consumption of Cardiac Muscle During Shock

Publisher Website
Google Scholar
Abstract
Shock was produced in rats of the Sprague-Dawley strain both by bleeding and by release of tourniquets applied previously to the hind limbs. The success of treatment in producing shock was gauged by the level of serum amino acid N and the appearance of the animals. The avg. increase in amino acid N with treatment was 2.97 mg. %. Respiration of slices of cardiac muscle was detd. by the direct method of Warburg at various times after treatment. Initially an increase in O2 consumption occurred, and was followed by decreased Q02 in 3 or 4 hrs. A secondary increase then occurred 5 and 6 hrs. after release of tourniquets, presumably associated with recovery. O2 consumption was increased by the addition of Na pyruvate substrate to the medium, but the relative changes descr. were not altered.