Purinergic Inhibition of Neurotransmitter Release in the Central Nervous System
- 1 November 1995
- journal article
- review article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 77 (5) , 299-305
- https://doi.org/10.1111/j.1600-0773.1995.tb01031.x
Abstract
Neurotransmitter release and the role of adenosine in its regulation has been investigated for more than twenty years, and it is now widely accepted that adenosine tonically inhibits the release of excitatory neurotransmitters. This effect of adenosine is operated by an A1adenosine receptor. Since activation of this receptor could inhibit Ca2+conductance, increase K+conductance, inhibit adenylate cyclase or phospholipase C, it is not clear if there is only one mechanism or several mechanisms operated by adenosine to inhibit neurotransmitter release, and in that case, what is the relative importance of each mechanism. The mechanism by which adenosine inhibits evoked synchronous transmitter release might be different from that used by the nucleoside to inhibit spontaneous asynchronous release. In some systems adenosine triphosphateper seacts like adenosine and inhibits neurotransmitter release. However, in most cases the inhibitory effect of this adenine nucleotide depends upon its hydrolysis into adenosine by a cascade of ectoenzymes, the last step being mediated by ecto‐5′‐nucleotidase.Keywords
This publication has 67 references indexed in Scilit:
- Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functionsTrends in Pharmacological Sciences, 1994
- Preferential inhibition of oω-conotoxin-sensitive presynaptic Ca2+ channels by adenosine autoreceptorsNature, 1993
- Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slicesHippocampus, 1993
- Ecto‐5′‐Nucleotidase Is Associated with Cholinergic Nerve Terminals in the Hippocampus but Not in the Cerebral Cortex of the RatJournal of Neurochemistry, 1992
- Extracellular adenosine 5′-triphosphate-evoked glutamate release in cultured hippocampal neuronsNeuroscience Letters, 1992
- In vivo pertussis toxin treatment attenuates some, but not all, adenosine A1 effects in slices of the rat hippocampusEuropean Journal of Pharmacology: Molecular Pharmacology, 1989
- Adenosine Inhibition of Histamine‐Stimulated Inositol Phospholipid Hydrolysis in Mouse Cerebral CortexJournal of Neurochemistry, 1988
- Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapsesNature, 1987
- Pertussis toxin reverses adenosine inhibition of neuronal glutamate releaseNature, 1985
- Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthinesLife Sciences, 1981