CALCIUM CHANGES IN THE PLASMA RESULTING FROM BRIEF SEVERE WORK AND THE QUESTION AS TO THE PERMEABILITY OF THE CAPILLARIES TO CALCIUM

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Abstract
Normal young men served as subjects in expts. in which work to exhaustion in 1 min. was performed (running, rowing or standing running). Blood samples were taken immediately before and after work and at intervals during recovery. Immediately after this brief severe exercise the plasma Ca concn. was markedly higher than in rest, the rise being as much as 17%. After the peak was reached the plasma Ca declined approximately along a logarithmic line until the resting level was reached (30-70 min.). The changes in [Ca] were closely parallel to changes in plasma protein concn. It is concluded that these concn. changes result almost entirely from exchanges of water between blood and tissue and that under these conditions even the so-called "diffusible" Ca is restrained from diffusion to the same extent as plasma proteins. It follows that the "diffusible" Ca will be osmotically active in the blood stream. The magnitude of this activity is calculated for the present expts. to be of the order of 30-60 mm. of water.

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