A note on the effects of 2, 4-diamino-5-phenylthiazole and 1, 2, 3, 4-tetrahydro-9-aminoacridine on morphine metabolism
- 1 October 1968
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 20 (10) , 763-767
- https://doi.org/10.1111/j.2042-7158.1968.tb09635.x
Abstract
Chromatographs of extracts of urine from patients receiving mixtures of morphine plus amiphenazole or morphine plus 1, 2, 3, 4-tetrahydro-9-aminoacridine (tha) have a spot which is due to a substance with properties similar to morphine-N-oxide. This spot was not present in urine of patients given morphine, amiphenazole or tha alone. Morphine-N-oxide may be a metabolite of morphine, and amiphenazole and tha may inhibit the further metabolism of morphine-N-oxide.Keywords
This publication has 12 references indexed in Scilit:
- Microsomal Dealkylation of DrugsJournal of Pharmaceutical Sciences, 1966
- Metabolism of Chlorpromazine. III. Isolation and Identification of Chlorpromazine-N-Oxide.Experimental Biology and Medicine, 1962
- Treatment of Intractable Pain with Morphine and TetrahydroaminacrineBMJ, 1961
- Amiphenazole and Morphine in Production of AnalgesiaBMJ, 1958
- Photometric Determination of 2:4-diamino-5-phenylthiazoleJournal of Pharmacy and Pharmacology, 1956
- Further Experience with Amiphenazole and Morphine in Intractable PainBMJ, 1956
- Treatment of Intractable Pain with Large Doses of Morphine and Diamino-phenylthiazoleBMJ, 1955
- Morphine AntagonistsNature, 1955
- Oxidative N-dealkylationBiochimica et Biophysica Acta, 1954
- Einwirkung von Wasserstoffsuperoxyd auf Thebain, Morphin und dessen ÄtherEuropean Journal of Inorganic Chemistry, 1910