Heparin cofactor II in diabetic patients

Abstract
Levels of heparin cofactor II (HCII) activity and antigen and electrophoretic pattern were studied both in normal subjects and in type I diabetic patients with high and normal levels of glycosylated haemoglobin. There was a significant reduction in HCII activity (83 ± 7%) in patients with high levels of glycosylated haemoglobin compared with controls (95 ± 17%; P < 0.001). However, plasma HCII antigen levels were not decreased in these patients.

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