HOMOGRAFT-INDUCED PRECIPITINS TO SERUM ISOANTIGENS

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Abstract
Evidence has been presented that allogeneic skin homografts may elicit formation of isoprecipitins directed against serum components. Of 24 rabbits grafted with skin from randomly selected donors, one produced isoprecipitins. This immune serum detected two antigens. One, a lipoprotein, was present in 38.8% of the rabbits tested. The other antigen which could not be characterized was found in 5.5% of the rabbits tested. A second precipitin-containing serum was found among 12 recipients which along with their donors had been selected for grafting on the basis of their serum reactions with the previously described antiserum. This antiserum detected a third serum antigen, an α -globulin, which was found in 72% of the rabbits tested. One guinea pig of 31 which had been grafted with allogeneic skin formed isoprecipitins against a serum antigen, probably γ -globulin, which was present in 41.3% of the guinea pigs tested.

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