Trypanosomiasis: An Approach to Chemotherapy by the Inhibition of Carbohydrate Catabolism
- 8 October 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4261) , 204-206
- https://doi.org/10.1126/science.986688
Abstract
When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.This publication has 8 references indexed in Scilit:
- The potential use of inhibitors of glycerol‐3‐phosphate oxidase for chemotherapy of African trypanosomiasisFEBS Letters, 1976
- BIOCHEMISTRY OF PROTOZOAN MICROBODIES: Peroxisomes, α-Glycerophosphate Oxidase Bodies, HydrogenosomesAnnual Review of Microbiology, 1975
- Influence of methods of preparation on the infectivity, agglutination, activity, and ultrastructure of bloodstream trypanosomesExperimental Parasitology, 1974
- m‐Chlorobenzhydroxamic Acid–an Inhibitor of Cyanide‐Insensitive Respiration in Trypanosoma brucei*The Journal of Protozoology, 1973
- Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangersNature, 1968
- Studies on the metabolism of the protozoa. 9. Comparative metabolism of blood-stream and culture forms of Trypanosoma rhodesienseBiochemical Journal, 1962
- Properties of l-α-glycerophosphate oxidase and its role in the respiration of Trypanosoma rhodesienseBiochemical Journal, 1960
- Studies on the metabolism of the protozoa. 7. Comparative carbohydrate metabolism of eleven species of trypanosomeBiochemical Journal, 1956