Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks
- 5 August 2010
- journal article
- research article
- Published by Elsevier in DNA Repair
- Vol. 9 (8) , 929-936
- https://doi.org/10.1016/j.dnarep.2010.05.007
Abstract
No abstract availableKeywords
This publication has 48 references indexed in Scilit:
- DNA polymerase β and PARP activities in base excision repair in living cellsDNA Repair, 2009
- PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATMDNA Repair, 2009
- Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMSMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2009
- PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombinationThe EMBO Journal, 2009
- Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibitionDNA Repair, 2008
- XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaksCell Research, 2008
- Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiencyDNA Repair, 2007
- ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activityDNA Repair, 2007
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationNature, 2003
- Role of poly(ADP-ribose) formation in DNA repairNature, 1992