Clozapine: the Holywell experience with the first 24 patients
- 1 February 1993
- journal article
- case report
- Published by Cambridge University Press (CUP) in Irish Journal of Psychological Medicine
- Vol. 10 (1) , 30-34
- https://doi.org/10.1017/s0790966700013288
Abstract
Clozapine was substituted for standard antipsychotic drugs in the treatment of 24 chronic schizophrenic inpatients and the response assessed after a mean of ten months. The majority (71%) improved (33.3% markedly), on their previous level of functioning. The response was better in those under 40 years of age, but neither duration of illness nor previous neuroleptic dose appeared to predict response to clozapine. The drug was ultimately discontinued in five (21%) patients – in three because of non-response and intolerance of sedation and in two because of neutropenia.Keywords
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