Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation
- 1 May 2000
- journal article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 11 (5) , 1709-1725
- https://doi.org/10.1091/mbc.11.5.1709
Abstract
Hepatocyte growth factor (HGF), the ligand for the Met receptor tyrosine kinase, is a potent modulator of epithelial–mesenchymal transition and dispersal of epithelial cells, processes that play cr...Keywords
This publication has 77 references indexed in Scilit:
- Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel PathwayJournal of Biological Chemistry, 1998
- Induction of epithelial branching tubulogenesis in vitroJournal of Cellular Physiology, 1997
- Hepatocyte Growth Factor (HGF) as a Tissue Organizer for Organogenesis and RegenerationBiochemical and Biophysical Research Communications, 1997
- Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsCurrent Biology, 1997
- RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun KinaseScience, 1996
- Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathwayCurrent Biology, 1996
- Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase ActivationJournal of Biological Chemistry, 1995
- Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells Requires Phosphatidylinositol 3-KinaseJournal of Biological Chemistry, 1995
- Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane rufflingPublished by Elsevier ,1994
- The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsCell, 1992