In Vitro Studies of BB-K8, a New Aminoglycoside Antibiotic

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Abstract
BB-K8, an aminoglycoside antibiotic which is a derivative of kanamycin, was tested in vitro against 466 clinical bacterial isolates. Over 90% of gram-negative bacilli, except Proteus spp., were inhibited by 3.12 μg of BB-K8 per ml. This antibiotic was consistently more active than kanamycin but less active than tobramycin or gentamicin. Unlike kanamycin, BB-K8 was active against Pseudomonas aeruginosa . Eleven of 19 isolates resistant to either gentamicin or tobramycin, or both, were susceptible to BB-K8.