Anti-IgA Antibodies in Two Brothers with Selective Serum IgA Deficiency
- 1 January 1975
- journal article
- case report
- Published by S. Karger AG in Acta Haematologica
- Vol. 54 (5) , 312-320
- https://doi.org/10.1159/000208091
Abstract
A selective serum IgA deficiency with anti-IgA antibodies at high titer were found in a patient who suffered severe transfusion reactions. The same abnormalities were detected in his brother, a 72-year-old-man in good general condition. Anti-IgA antibodies were found in the IgG fraction and were directed against alpha-chains. A deficiency of isoagglutinins and an absence of heteroagglutinins in the propositus' serum could be shown.Keywords
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